Galectin-8/LGALS8 蛋白, Rat (His)

Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. Galectin-8 inhibits MTOR and AMPK signaling pathways to induce autophagy in response to lysosomal damage. Galectin-8 is highly expressed in a variety of tumors. Galectin-8/LGALS8 Protein, Rat (His) is the recombinant rat-derived Galectin-8, expressed by E. coli , with N-6*His labeled tag.

半乳糖凝集素-8 (Galectin-8) 属于动物凝集素家族，可结合不同的糖缀合物。作为一种分泌蛋白，Galectin-8 存在于体液中或乳腺癌患者的血清和结肠癌患者的血清中。细胞外 Galectin-8 通过与细胞粘附分子如整合素 CD44、CD166 和 Podoplanin 结合，促进细胞粘附。Galectin-8 通过标记病原体入侵的空泡被自噬破坏来发挥细胞内功能。在溶酶体损伤引起的膜扰动中，Galectin-8 抑制 MTOR 和 AMPK 响应溶酶体损伤诱导自噬。Galectin-8 在多种肿瘤中高表达。

Measured by its binding ability in a functional ELISA. Immobilized SLC31A1 at 5 μg/mL (100 μL/well) can bind Rat Galectin-8. The ED₅₀ for this effect is 3.773 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized SLC31A1 at 5 μg/mL (100 μL/well) can bind Rat Galectin-8, The ED₅₀ for this effect is 3.773 μg/mL.

Rat

E. coli

N-6*His

Q6IN24 (M1-W316)

116641

MLSLSNLQNIIYNPTIPYVSTITEQLKPGSLIVIRGHVPKDSERFQVDFQHGNSLKPRADVAFHFNPRFKRSNCIVCNTLTNEKWGWEEITHDMPFRKEKSFEIVIMVLKNKFQVAVNGKHILLYAHRINPEKIDTLGIYGKVNIHSIGFRFSSDLQSMETSTLGLTQISKENIQKSGKLHLSLPFEARLNASMGPGRTVVVKGEVNTNAKSFNVDLVAGRSRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKDLSSIDTLAVDGDIRLLDVRSW

Approximately 34 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 10% glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.