IL-20 蛋白, Human

IL-20 Protein, Human is a member of the IL-10 family of cytokines. Interleukin-20 binds to the IL-20 heterodimeric receptor with a K_d of 1.5 nM.

转基因 (TG) 小鼠中白细胞介素 20 (IL-20) 的过度表达会导致新生儿死亡，并伴有皮肤异常，包括表皮分化异常。重组 IL-20 蛋白通过角质形成细胞系中的 STAT3 刺激信号转导途径，证明了该配体的直接作用。IL-20 受体被鉴定为两个孤儿 II 类细胞因子受体亚基的异二聚体^[1]。

The ED₅₀ is <0.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >2.0 × 10⁶ units/mg.

Human

E. coli

Tag Free

Q9NYY1-1 (L25-E176)

50604  [NCBI]

MLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE

Approximately 17.6 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.2, with trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Blumberg H, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 2001 Jan 12;104(1):9-19.  [Content Brief]