1. 重组蛋白
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. C-type Lectin Receptors
  5. Killer Cell Lectin Like Receptor G1 (KLRG1)
  6. KLRG1 蛋白, Mouse (HEK293, Fc)

KLRG1 蛋白, Mouse (HEK293, Fc)

目录号: HY-P77974
产品使用指南

KLRG1 蛋白通过与非 MHC 配体结合,在抑制 NK 细胞和 T 细胞功能中发挥关键作用。它参与自我识别缺失,监测 E-钙粘蛋白/CDH1 等经典钙粘蛋白的表达。KLRG1 以单体或同二聚体形式存在,利用其 ITIM 与 PTPN11 和 INPP5D 相互作用,调节细胞反应并有助于免疫调节。KLRG1 蛋白, Mouse (HEK293, Fc) 是重组的 KLRG1 蛋白,由 HEK293 表达,带有 N-hFc 标签。KLRG1 蛋白, Mouse (HEK293, Fc) 全长 132 个氨基酸,分子量为 43-50 kDa。

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描述

KLRG1 Protein plays a pivotal role in inhibiting NK cells and T-cell functions by binding to non-MHC ligands. It engages in missing self-recognition, monitoring the expression of classical cadherins like E-cadherin/CDH1. Existing as a monomer or homodimer, KLRG1 employs its ITIM to interact with PTPN11 and INPP5D, modulating cellular responses and contributing to immune regulation. KLRG1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived KLRG1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of KLRG1 Protein, Mouse (HEK293, Fc) is 132 a.a., with molecular weight of 43-50 kDa.

研究背景

KLRG1 蛋白通过与非 MHC 配体结合,在对自然杀伤 (NK) 细胞和 T 细胞功能发挥抑制作用方面发挥着关键作用。通过参与缺失的自我识别,KLRG1 监测靶细胞上经典钙粘蛋白的表达,包括 E-钙粘蛋白/CDH1、N-钙粘蛋白/CDH2 和 R-钙粘蛋白/CDH4。KLRG1 以带有二硫键的单体和同型二聚体形式存在,利用其基于酪氨酸的免疫受体抑制基序 (ITIM) 与 PTPN11 和 INPP5D 等信号分子相互作用,从而调节细胞反应并有助于免疫调节。

种属

Mouse

表达系统

HEK293

标签

N-hFc

蛋白编号

O88713 (Q57-Y188)

基因 ID
蛋白结构
N-term
hFc
KLRG1 (Q57-Y188)
Accession # O88713
C-term
同用名
KLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600
分子量

43-50 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
KLRG1 Protein, Mouse (HEK293, Fc)
目录号:
HY-P77974
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