MKNK2 蛋白, Human (His)

MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human (His) is the recombinant human-derived MKNK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MKNK2 Protein, Human (His) is 314 a.a., .

MKNK2 是一种丝氨酸/苏氨酸蛋白激酶，通过磷酸化 SFPQ/PSF、HNRNPA1 和 EIF4E 在细胞过程中发挥关键作用。MKNK2 位于环境应激和细胞因子信号转导的交叉点，通过 EIF4E 磷酸化参与翻译调节。这种磷酸化增强了 EIF4E 对含有 7-甲基鸟苷的 mRNA 帽的亲和力，从而影响翻译机制。此外，MKNK2 对于介导 EIF4E 从细胞质到细胞核的穿梭至关重要。值得注意的是，异构体 1 表现出较高的基础激酶活性，而异构体 2 则表现出明显较低的激酶活性。MKNK2 是 IFNγ 对造血抑制作用的关键介质，并在控制三氧化二砷 As(2)O(3) 诱导的细胞凋亡和抗白血病反应的信号通路中充当负调节因子。此外，MKNK2 错综复杂地参与血清撤药触发的抗凋亡信号传导。

Human

E. coli

N-6*His

Q9HBH9 (T72-R385)

2872

37.4 kD

Greater than 80% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.