OSM 蛋白, Mouse (HEK293, His)

OSM protein is a multifunctional growth regulator that effectively inhibits the proliferation of tumor cell lines and regulates the production of cytokines, including IL-6, G-CSF, and GM-CSF produced by endothelial cells.It specifically binds to type II OSM receptors, forming a heterodimer composed of OSMR and IL6ST.OSM Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSM protein, expressed by HEK293 , with C-His labeled tag.

OSM 蛋白作为一种多功能生长调节剂而出现，具有抑制各种肿瘤细胞系增殖的强大能力。这种多方面的蛋白质将其影响扩展到细胞因子产生的调节，包括内皮细胞的 IL-6、G-CSF 和 GM-CSF。OSM 专门与 II 型 OSM 受体结合，形成由 OSMR 和 IL6ST 组成的异二聚体。除了其抗增殖作用外，OSM 还与胎儿肝细胞的成熟密切相关，在促进肝脏发育和再生方面发挥着关键作用。

Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is 0.4530 ng/mL, corresponding to a specific activity is 2.206×10⁶ U/mg.

Mouse

HEK293

C-His

P53347 (N25-R206)

18413  [NCBI]

35-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.