OTUD5 蛋白, Human (His, FLAG)

The OTUD5 protein is a deubiquitinating enzyme that crucially eliminates the innate immune response through peptidase activity on "Lys-48" and "Lys-63" linked polyubiquitin chains, thereby inhibiting TRAF3-mediated Type I interferon production. It acts as a regulator of neuroectodermal differentiation by cleaving “Lys-48” linked ubiquitin chains to prevent the degradation of chromatin regulators such as ARID1A, HDAC2 and HCF1. OTUD5 Protein, Human (His, FLAG) is the recombinant human-derived OTUD5 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of OTUD5 Protein, Human (His, FLAG) is 180 a.a., .

OTUD5 蛋白是一种去泛素化酶，作为先天免疫系统的负调节剂发挥着至关重要的作用，对“Lys-48”和“Lys-63”连接的多聚泛素链表现出肽酶活性，并且能够裂解“Lys-”体外 11'-连接的泛素链。它通过 TRAF3 去泛素化发挥作用，随后抑制 I 型干扰素 (IFN) 的产生。此外，OTUD5 作为神经外胚层分化的关键控制器，通过裂解“Lys-48”连接的泛素链来抵消 ARID1A、HDAC2 和 HCF1 等必需染色质调节因子的降解。此外，在被 MTOR 磷酸化后，OTUD5 充当 mTORC1 和 mTORC2 信号传导的正调节因子，介导 BTRC 的去泛素化并增强其稳定性。这种多方面的作用强调了 OTUD5 在调节多种细胞过程中的重要性，强调了它对免疫调节、细胞分化和信号通路的关键贡献。

Human

E. coli

N-His;C-Flag

Q96G74 (G172-G351)

55593

Approximately 23.9 KDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.