PMM1 蛋白, Human (His)

The PMM1 protein is key to the synthesis of GDP-mannose and polyethylene glycol-phosphate-mannose and is essential for the mannosyl transfer reaction. Its enzymatic activity contributes to the biosynthesis of mannose-containing glycoconjugates, which are critical for protein glycosylation and related cellular processes. PMM1 Protein, Human (His) is the recombinant human-derived PMM1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of PMM1 Protein, Human (His) is 262 a.a., with molecular weight of ~49.0 kDa.

PMM1 蛋白在 GDP-甘露糖和多甘醇-磷酸-甘露糖的合成中发挥着关键作用，对于各种重要的甘露糖基转移反应至关重要。其酶活性有助于含甘露糖复合糖的生物合成，在蛋白质糖基化和相关细胞过程中发挥着至关重要的作用。此外，PMM1 可能在缺血性大脑中葡萄糖-1,6-二磷酸的降解中发挥额外作用，表明它参与了对缺血条件的代谢反应。PMM1 的多方面功能强调了其在细胞稳态中的重要性，并强调了其在特定生理环境下对糖基化过程和代谢适应的潜在贡献。

Human

E. coli

C-6*His

Q92871 (M1-A262)

5372  [NCBI]

MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIAEQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSVVSPQDTVQRCREIFFPETAHEA

Approximately 49.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.