TPBG/5T4 蛋白, Human (HEK293, hFc)

TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This means that TPBG/5T4 plays a crucial role in regulating the complex Wnt/β-catenin signaling pathway and exerts a regulatory influence on cellular responses related to this pathway. TPBG/5T4 Protein, Human (HEK293, hFc) is the recombinant human-derived TPBG/5T4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TPBG/5T4 Protein, Human (HEK293, hFc) is 324 a.a., with molecular weight of 75-105 kDa.

TPBG/5T4 蛋白似乎可作为 Wnt/β-连环蛋白信号传导的抑制剂，可能通过与 LRP6 间接相互作用来实现，从而阻止 Wnt3a 依赖性 LRP6 内化。这意味着 TPBG/5T4 在调节复杂的 Wnt/β-catenin 信号通路中发挥着至关重要的作用，并对与该通路相关的细胞反应产生调节影响。进一步探索控制 TPBG/5T4 和 LRP6 之间相互作用的特定分子机制，及其对 Wnt3a 依赖性 LRP6 内化的影响，可以对 TPBG/5T4 在塑造 Wnt/β-catenin 信号动力学中的功能意义产生有价值的见解及其对各种细胞过程的潜在影响。

Immobilized Human TPBG, hFc Tag at 0.5 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Anti-TPBG Antibody, hFc Tag with the EC₅₀ of ≤30 ng/mL determined by ELISA.

Human

HEK293

C-hFc

Q13641 (S32-S355)

7162  [NCBI]

75-105 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.