TXNL4A 蛋白, Human (His)

The TXNL4A protein plays a key role in pre-mRNA splicing and is an important component of U5 snRNP, U4/U6-U5 tri-snRNP complex, and precatalytic spliceosome (spliceosome B complex). It contributes to spliceosome assembly and is an integral part of the complex process of spliceosome function. TXNL4A Protein, Human (His) is the recombinant human-derived TXNL4A protein, expressed by E. coli , with N-His labeled tag. The total length of TXNL4A Protein, Human (His) is 142 a.a., with molecular weight of ~14 kDa.

TXNL4A 蛋白是前 mRNA 剪接的组成部分，是 U5 snRNP 和 U4/U6-U5 tri-snRNP 复合物中的关键成分，对于剪接体组装和预催化剪接体（剪接体 B 复合物）的形成都是必需的。在由 U4、U6 和 U5 snRNA 组成的 U4/U6-U5 tri-snRNP 复合物中，TXNL4A 与多种蛋白质（包括 PRPF3、PRPF4、PRPF6、PRPF8 等）协作，为预催化剪接体奠定基础。它与 CD2BP2 的直接相互作用以及与 HNRPF、HNRPH2、NEDD9 和 PQBP1 等蛋白质的关联突出了 TXNL4A 在编排前 mRNA 剪接的复杂机制中的多方面参与。此外，TXNL4A 与 ERBB4 相互作用，展示了其与更广泛的细胞过程的潜在联系。

Human

E. coli

N-His

P83876 (M1-Y142)

10907  [NCBI]

MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY

Approximately 14 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.