VEGF164 蛋白, Rat (sf9)

The VEGF164 protein is a growth factor critical for vasculogenesis, vasculogenesis, and endothelial cell growth, inducing proliferation, promoting migration, inhibiting apoptosis, and enhancing vascular permeability. It binds to FLT1/VEGFR1, KDR/VEGFR2, heparan sulfate, heparin, NRP1 and DEAR/FBXW7-AS1 receptors. VEGF164 Protein, Rat (sf9) is the recombinant rat-derived VEGF164 protein, expressed by Sf9 insect cells , with tag free. The total length of VEGF164 Protein, Rat (sf9) is 164 a.a., with molecular weight of ~25 kDa.

VEGF164 是一种在血管生成、血管形成和内皮细胞生长中发挥关键作用的生长因子，协调一系列对血管发育至关重要的细胞反应。它通过与FLT1/VEGFR1和KDR/VEGFR2等受体以及硫酸乙酰肝素和肝素结合，刺激内皮细胞增殖，促进细胞迁移，防止细胞凋亡，并增强血管通透性。在哺乳期间，VEGF164 可能有助于增加血管通透性，支持乳蛋白合成分子的有效运输。此外，它与 NRP1 受体的相互作用启动了运动神经元轴突引导和细胞迁移所必需的信号通路，强调了它参与胚胎发育过程。VEGF164 作为具有二硫键的同二聚体存在，也与 PGF 形成异二聚体，并与 BSG 的亚型 2 相互作用，揭示了其多方面的分子相互作用。

Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC) and the ED₅₀ is typically 1-10 ng/mL.

Rat

Sf9 insect cells

Tag Free

P16612-2 (A27-R190)

83785  [NCBI]

Approximately 25 kDa

Greater than 86% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 100 mM Glycine, 10 mM NaCl, pH 7.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.