2. Cell Cycle/DNA Damage Epigenetics NF-κB
  3. HDAC NF-κB
  4. SAP15

SAP15  (Synonyms: Synthetic anti-inflammatory peptide 15)

目录号: HY-P10462
产品使用指南

摩尔计算器

SAP15 (Synthetic anti-inflammatory peptide 15) 是一种由人类 β-防御素3 设计的 15 个氨基酸组成的合成抗炎肽。SAP15 具有穿透细胞的能力，并能够诱导细胞内炎症的下调。SAP15 通过抑制 HDAC5 的磷酸化，从而减少 NF-κB p65 的磷酸化，进而抑制炎症反应。在 LPS 诱导的巨噬细胞中，SAP15 能够抑制 HDAC5 和 NF-κB p65 的磷酸化。此外，SAP15 处理增加了 LPS 诱导的软骨细胞中 aggrecan 和 II 型胶原的表达，并减少了骨钙素的表达。SAP15 可用于生物材料的炎症调节和抗炎治疗的研究。

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SAP15 Chemical Structure

SAP15 Chemical Structure

CAS No. : 1403753-45-6

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规格 是否有货
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Customer Review

SAP15 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials[1].

分子量

1767.16

Formula

C68H131N31O18S3
CAS 号
Sequence

Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys
Sequence Shortening

GKCSTRGRKCCRRKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAP15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAP151403753-45-6Synthetic anti-inflammatory peptide 15SAP 15SAP-15HDACNF-κBHistone deacetylasesNuclear factor-κBNuclear factor-kappaBCell penetrationinflammatory responsephosphorylation inhibitioncollagenosteocalcinbiomaterialsInhibitorinhibitorinhibit

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