2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. ST7710AA1

T7710AA1 (compound 1l) 是一种有效的 PARP-1 抑制剂，其 IC50 值为 0.07 µM。ST7710AA1 表现出抗增殖活性。ST7710AA1 表现出抗癌活性。

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ST7710AA1 Chemical Structure

ST7710AA1 Chemical Structure

CAS No. : 1542067-20-8

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ST7710AA1 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC50 value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity[1].

IC50 & Target[1]

PARP-1

0.07 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
2.9 μM
Compound: 1l, ST7710AA1
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
[PMID: 24398383]
CAPAN-1 IC50
22.04 μM
Compound: 1l, ST7710AA1
Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
[PMID: 24398383]
HCC1937 IC50
19.43 μM
Compound: 1l, ST7710AA1
Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
[PMID: 24398383]
HeLa EC50
400 nM
Compound: 1l, ST7710AA1
Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
[PMID: 24398383]
体外研究
(In Vitro)

ST7710AA1 (compound 1l) (0-200 µM; 72 h) 表现出抗增殖作用，对 HCC1937、Capan 1 细胞的 IC50 值分别为 19.43、22.04 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ST7710AA1 相关抗体:
体内研究
(In Vivo)

ST7710AA1 (100 mg/kg; i.p.; every 2 days for 2 weeks) 在小鼠中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.41

Formula

C20H22N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ST7710AA1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST7710AA11542067-20-8PARPpoly ADP ribose polymeraseHCC1937Capan 1antiproliferativeanticancerInhibitorinhibitorinhibit

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ST7710AA1
目录号：
HY-117423
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