Sulprostone  (Synonyms: 硫前列酮; SHB 286; CP-34089; ZK-57671)

Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery^[1][2][3].

Sulprostone (SHB 286) has K_i values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells^[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T_1/2 of 0.451 hours, a CL of 56 mL/min•kg, a V_ss of 0.583 L/kg and an AUC of 149 ng•h/mL^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

465.56

C₂₃H₃₁NO₇S

60325-46-4

液体

Colorless to light yellow

硫前列酮

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. S Narumiya, et al. Prostanoid receptors: structures, properties, and functions. Physiol Rev. 1999 Oct;79(4):1193-226.  [Content Brief]

  [2]. Jenny Bulgarelli, et al. Skewing effect of sulprostone on dendritic cell maturation compared with dinoprostone. Cytotherapy. 2018 Jun;20(6):851-860.  [Content Brief]

  [3]. Yifan Shi, et al. Bioanalysis of sulprostone, a prostaglandin E 2 analogue and selective EP 3 agonist, in monkey plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:51-57.  [Content Brief]