2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Tariquidar dimesylate

Tariquidar dimesylate  (Synonyms: XR9576 dimesylate)

目录号: HY-10550B
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摩尔计算器

Tariquidar dimesylate (XR9576 dimesylate) 是一种 P-glycoprotein (P-gp) 抑制剂。Tariquidar dimesylate 通过与 P-glycoprotein 结合，阻止其将药物从脑内向外运输，从而增加药物在脑内的浓度。Tariquidar dimesylate 可用于血脑屏障穿透性和多药耐药性的研究。

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Tariquidar dimesylate Chemical Structure

Tariquidar dimesylate Chemical Structure

CAS No. : 625375-84-0

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Tariquidar dimesylate 的其他形式现货产品:

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Tariquidar dimesylate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 49 篇科研文献

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WB

    Tariquidar dimesylate purchased from MCE. Usage Cited in: Eur J Med Chem. 2017 Feb 15;127:586-598.  [Abstract]

    Fluorescence ratio values in K562/DOX cells incubated with Rhd 123 in the absence (control) and in the presence of Verapamil (ver.) and Tariquidar (tar.) tested at 3.0 μM and 1.0 μM concentrations respectively.

    Tariquidar dimesylate purchased from MCE. Usage Cited in: RSC Adv. 2016,6, 69083-69093.

    Western blot analysis on MCF-7/ADR cells after being treated by (A) control (without treatment), (B) free DOX, (C) CMC/CaCO3/DOX, (D) BCMC/CaCO3/DOX, (E) CMC/CaCO3/DOX/TQR, and (F) BCMC/CaCO3/DOX/TQR for 24 h.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance[1].

    分子量

    838.94

    Formula

    C40H46N4O12S2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Tariquidar dimesylate 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tariquidar dimesylate625375-84-0XR9576 dimesylateP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Blood-brain barrierMultidrug resistanceInhibitorinhibitorinhibit

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