2. Academic Validation
  3. Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity

Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity

  • J Nat Prod. 2022 Nov 22. doi: 10.1021/acs.jnatprod.2c00677.
Elena V Leshchenko 1 2,  Alexandr S Antonov 2,  Sergey A Dyshlovoy 1 3 4,  Dmitrii V Berdyshev 2,  Jessica Hauschild 3 4,  Olesya I Zhuravleva 1 2,  Gleb V Borkunov 1,  Alexander S Menshov 2,  Natalya N Kirichuk 2,  Roman S Popov 2,  Andrey V Gerasimenko 5,  Anatoly A Udovenko 5,  Markus Graefen 4,  Carsten Bokemeyer 3,  Gunhild von Amsberg 3 4,  Anton N Yurchenko 2
Affiliations

Affiliations

  • 1 Institute of High Technologies and Advanced Materials, Far Eastern Federal University, Vladivostok 690922, Russian Federation.
  • 2 G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russian Federation.
  • 3 Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • 4 Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • 5 Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russian Federation.
PMID: 36413729 DOI: 10.1021/acs.jnatprod.2c00677
Abstract

New meroterpenoids, meroantarctines A-C (1-3), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticum KMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1-3 was proposed. Meroantarctines A-C (1-3) inhibited P-glycoprotein activity and could resensitize drug-resistant Cancer cells to docetaxel.

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