1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. Tinostamustine hydrochloride

Tinostamustine hydrochloride  (Synonyms: EDO-S101 hydrochloride; NL-101 hydrochloride)

目录号: HY-101780A
产品使用指南

Tinostamustine hydrochloride (EDO-S101 hydrochloride)是一种具有抗多发性骨髓瘤活性的化合物,具有促进CD38表达的能力。Tinostamustine hydrochloride通过增加组蛋白H3的乙酰化水平,增强肿瘤细胞对抗CD38单克隆抗体daratumumab的敏感性。Tinostamustine hydrochloride能够增加MICA和MICB的表达,进而激活NK细胞。Tinostamustine hydrochloride可以显著延迟肿瘤生长,提高小鼠的生存率。

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Tinostamustine hydrochloride Chemical Structure

Tinostamustine hydrochloride Chemical Structure

CAS No. : 1793059-58-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice[1].

分子量

451.82

Formula

C19H29Cl3N4O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tinostamustine hydrochloride
目录号:
HY-101780A
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