2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU0448088

VU0448088 (ML253) 是一种有效的、可穿过血脑屏障的三环毒蕈碱乙酰胆碱受体亚型 4 (tricyclic muscarinic acetylcholine receptor subtype 4 (M4)) 正变构调节剂，对人和大鼠的 EC50 值分别为 56, 176 nM。VU0448088 具有用于精神病研究的潜力。

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VU0448088 Chemical Structure

VU0448088 Chemical Structure

CAS No. : 1417616-42-2

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VU0448088 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

查看所有亚型
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic[1][2].

IC50 & Target[1]

mAChR4

56 nM (EC50)

体内研究
(In Vivo)

VU0448088 (3, 10, 30, 56.6, 100 mg/kg; i.p.) 以剂量依赖性方式逆转苯丙胺引起的运动亢进[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (amphetamine-induced hyperlocomotion)[1]
Dosage: 3, 10, 30, 56.6, 100 mg/kg
Administration: IP
Result: Reversed amphetamine-induced hyperlocomotion in a dose-dependent manner, showed a modest reduction of 26% at a dose of 10 mg/kg; at the three highest doses (30, 56.6 and 100 mg/kg), showed significant reductions of 47.9%, 53.7% and 57.3%, respectively.
分子量

346.83

Formula

C16H15ClN4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU0448088 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04480881417616-42-2ML253VU 0448088VU-0448088ML 253ML-253mAChRMuscarinic acetylcholine receptorblood-brain barrierpsychoticamphetamineInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162663
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