2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Drug-Linker Conjugates for ADC Apoptosis
  4. β-Glucuronide-dPBD-PEG5-NH2 TFA

β-Glucuronide-dPBD-PEG5-NH2 TFA 

目录号: HY-145736A
产品使用指南

摩尔计算器

β-Glucuronide-dPBD-PEG5-NH2 TFA 是 β-葡糖苷酸与 pyrrolobenzodiazepine 连接形成的二聚体，可与异戊二烯化的抗体结合形成抗体-活性分子偶联物 (ADC) cIRCR201-dPBD。β-葡糖苷酸键是一种可降解 (cleavable) 的 ADC Linker。β-Glucuronide-dPBD-PEG5-NH2 TFA 作为 cIRCR201-dPBD 的前体可减少副作用。β-Glucuronide-dPBD-PEG5-NH2 TFA 可诱导细胞凋亡 (apoptosis)，阻滞细胞周期。β-Glucuronide-dPBD-PEG5-NH2 TFA 具有抗肿瘤活性。

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β-Glucuronide-dPBD-PEG5-NH2 TFA Chemical Structure

β-Glucuronide-dPBD-PEG5-NH2 TFA Chemical Structure

CAS No. : 2246364-63-4

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Other Forms of β-Glucuronide-dPBD-PEG5-NH2 TFA:

β-Glucuronide-dPBD-PEG5-NH2 TFA 相关抗体

Top Publications Citing Use of Products

查看 Drug-Linker Conjugates for ADC 亚型特异性产品:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity[1].

IC50 & Target

Drug-linker conjugates for ADC, Apoptosis[1]
分子量

1810.69

Formula

C80H102F3N7O37
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Glucuronide-dPBD-PEG5-NH2 TFA 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Glucuronide-dPBD-PEG5-NH22246364-63-4Drug-Linker Conjugates for ADCApoptosisβ-glucuronide-linked pyrrolobenzodiazepine dimerantibody-drug conjugateADCcIRCR201-dPBDcleavable linkerprodrugreduces side effectsInhibitorinhibitorinhibit

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