2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR VD/VDR
  4. 11-Hydroxysugiol

11-Hydroxysugiol  (Synonyms: 11-羟基柳杉酚)

目录号: HY-107218
产品使用指南

摩尔计算器

11-Hydroxysugiol 通过调节 RARα 和维生素 D3 受体 (VDR) 来调节细胞内受体的 SUMOylation。

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11-Hydroxysugiol Chemical Structure

11-Hydroxysugiol Chemical Structure

CAS No. : 88664-08-8

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11-Hydroxysugiol 相关抗体

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RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D3 receptor (VDR)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 16
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
A549 GI50
35.04 μM
Compound: 12
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
BEAS-2B IC50
> 10 μM
Compound: 16
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
BXPC-3 GI50
45.01 μM
Compound: 12
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HeLa IC50
39.6 μM
Compound: 8
Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs
Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs
[PMID: 24709561]
HeLa IC50
41.1 μM
Compound: 8
Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs
Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs
[PMID: 24709561]
HEp-2 IC50
46.2 μM
Compound: 8
Cytotoxicity against human Hep2 cells in log phase of growth after 48 hrs
Cytotoxicity against human Hep2 cells in log phase of growth after 48 hrs
[PMID: 24709561]
HEp-2 IC50
49.4 μM
Compound: 8
Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs
Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs
[PMID: 24709561]
HL-60 IC50
> 10 μM
Compound: 16
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
HL-60 GI50
35.26 μM
Compound: 12
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
MCF7 IC50
> 10 μM
Compound: 16
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
MRC5 GI50
40.19 μM
Compound: 12
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PANC-1 GI50
43.14 μM
Compound: 12
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PC-3 GI50
41.03 μM
Compound: 12
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
RAW264.7 IC50
15.5 μM
Compound: 38
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 29924604]
SMMC-7721 IC50
> 10 μM
Compound: 16
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
SW480 IC50
> 10 μM
Compound: 16
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
Vero IC50
47.5 μM
Compound: 8
Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 hrs
Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 hrs
[PMID: 24709561]
Vero IC50
47.5 μM
Compound: 8
Cytotoxicity against African green monkey Vero cells in log phase of growth after 48 hrs
Cytotoxicity against African green monkey Vero cells in log phase of growth after 48 hrs
[PMID: 24709561]
分子量

316.43

Formula

C20H28O3
CAS 号
中文名称

11-羟基柳杉酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

11-Hydroxysugiol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11-Hydroxysugiol88664-08-811-羟基柳杉酚RAR/RXRVD/VDRRetinoic acid receptorsRetinoid X receptorsVitamin DVitamin D receptorSUMOylationRARαvitamin D3 receptorVDRInhibitorinhibitorinhibit

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