2. 天然产物
  3. 内源性代谢物 酮、醛、酸
  4. 14S(15R)-EET

14S(15R)-EET 是一种内源性在大鼠器官中主要存在的环氧三烯酸衍生物，通过研究其代谢过程发现，其立体选择性的水合作用和手性二醇的形成受到环氧化物酶的显著影响。不同的14,15-EET对映体显示出水合反应的不同区域和立体化学，其中14(R),15(S)-EET表现出对C15的特异性水合作用。这些发现揭示了环氧化物酶在内源性EET代谢中的重要作用，以及酶对个体EET对映体的亲和性和反应速率差异可能导致其立体选择性代谢。

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14S(15R)-EET Chemical Structure

14S(15R)-EET Chemical Structure

CAS No. : 105304-92-5

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14S(15R)-EET 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism[1].

分子量

320.47

Formula

C20H32O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

14S(15R)-EET 相关分类

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  • 稀释计算器

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Keywords:

14S(15R)-EET105304-92-5OthersInhibitorinhibitorinhibit

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