2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. 15(R)​-​15-​Methyl prostaglandin D2

15(R)​-​15-​Methyl prostaglandin D2  (Synonyms: 15(R)-15-Methyl PGD2)

目录号: HY-125782
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15(R)-15-Methyl prostaglandin D2 (15(R)-15-Methyl PGD2) 是一种代谢稳定的 PGD2 合成类似物。PGD2 的生理作用包括调节睡眠、降低体温、抑制血小板聚集和放松血管平滑肌。PGD2 通过 2 种不同的 G 蛋白偶联受体 DP1 和 CRTH2/DP2 介导其作用。15(R)-15-Methyl prostaglandin D2 是 CRTH2/DP2 受体的强效选择性激动剂。嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化性的 EC50 值分别为 1.4、3.8 和 1.7 nM，每个值都比 PGD2 低约 3-5 倍。相比之下，15(R)-15-甲基 PGD2 引起 DP1 介导的血小板 cAMP 增加的 EC50 为 >10 μM。

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15(R)​-​15-​Methyl prostaglandin D2 Chemical Structure

15(R)​-​15-​Methyl prostaglandin D2 Chemical Structure

CAS No. : 210978-26-0

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15(R)​-​15-​Methyl prostaglandin D2 相关抗体

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  • 生物活性

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生物活性

15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

分子量

366.49

Formula

C21H34O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
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15(R)​-​15-​Methyl prostaglandin D2 相关分类

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Keywords:

15(R)​-​15-​Methyl prostaglandin D2210978-26-015(R)-15-Methyl PGD2Prostaglandin ReceptorInhibitorinhibitorinhibit

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