2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. 15(R)-17-Phenyl trinor Prostaglandin F2α

15(R)-17-Phenyl trinor Prostaglandin F2α  (Synonyms: 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α)

目录号: HY-139121
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15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid) 是一种 F 系列前列腺素类似物，已用作眼部降压剂。我们实验室的研究表明，17-Phenyl trinor Prostaglandin F2α 乙基酰胺在人角膜中通过酰胺酶的酶活性转化为相应的游离酸，转化率约为 25 μg/角膜/24 hr。游离酸 17-Phenyl trinor Prostaglandin F2α 是一种有效的 FP 受体激动剂。15(R)-17-Phenyl trinor Prostaglandin F2α 是这种活性游离酸代谢物的 15-epi 或“非天然”异构体。它具有大大降低的 FP 受体介导活性，通常比 15(S)-异构体低 1.5 到 2 个对数。在人类和动物青光眼模型中，FP 受体激动剂活性与眼内降压活性非常接近。

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15(R)-17-Phenyl trinor Prostaglandin F2α Chemical Structure

15(R)-17-Phenyl trinor Prostaglandin F2α Chemical Structure

CAS No. : 41639-71-8

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15(R)-17-Phenyl trinor Prostaglandin F2α 相关抗体

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生物活性

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

分子量

388.50

Formula

C23H32O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

15(R)-17-Phenyl trinor Prostaglandin F2α 相关分类

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Keywords:

15(R)-17-Phenyl trinor Prostaglandin F2α41639-71-815-epi Bimatoprost15(R)-Bimatoprost 15(R)-17-phenyl trinor PGF2αProstaglandin ReceptorInhibitorinhibitorinhibit

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