2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2-Pyrrolidinone

2-Pyrrolidinone  (Synonyms: 2-吡咯烷酮; 2-吡咯酮; 2-Pyrrolidone)

目录号: HY-Y1831 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

2-Pyrrolidinone 是存在于甘蓝中的活性化合物，并显示抗癌特性。

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2-Pyrrolidinone Chemical Structure

2-Pyrrolidinone Chemical Structure

CAS No. : 616-45-5

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规格 价格 是否有货 数量
1 g ￥800
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Customer Review

2-Pyrrolidinone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Pyrrolidinone is an active compound present in Brassica oleracea var. capitata and displays anticancer property.

体外研究
(In Vitro)

Radical scavenging activity increases with increasing the amount of 2-Pyrrolidinone. The cytotoxicity of 2-Pyrrolidinone is found to be dose and time dependent, and the effect is observed microscopically in all of the selected cancer cell lines. It is observed that 2-Pyrrolidinone has cytotoxic concentrations of 2.5 mg/mL for HeLa, 3 mg/mL for PC-3 cells at 24 h and 1.5 mg/mL for HeLa and 2 mg/mL for PC-3 cells at 48 h, respectively. The cell viability decreases with increasing concentrations of purified 2-Pyrrolidinone. After treatment with 2-Pyrrolidinone their IC50 concentrations (1.5 mg/mL and 2 mg/mL for HeLa and PC-3 cells, respectively) for a period of 24 h, morphological changes in the cells are observed. It is demonstrated that 2-Pyrrolidinone induces apoptosis in HeLa and PC-3 cells via G0/G1phase of cell cycle arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Pyrrolidinone 相关抗体:
分子量

85.10

Formula

C4H7NO
CAS 号
性状

固体

颜色

White to off-white

中文名称

2-吡咯烷酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (1175.09 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 11.7509 mL 58.7544 mL 117.5088 mL
5 mM 2.3502 mL 11.7509 mL 23.5018 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Cell Assay
[1]

The inhibitory concentrations (IC50) are evaluated using an MTT assay. Cancer cells are grown (1×104 cells/well) in a 96-well plate for 48 h into 75% confluence. The medium is replaced with fresh medium containing concentration of (0.5 to 5 mg/mL) 2-Pyrrolidinone, and the cells are further incubated for 24 h and 48 h. The culture medium is removed, and 100 mL of the MTT solution is added to each well and incubated at 37°C for 4 h. After removal of the supernatant, 50 mL of DMSO is added to each of the wells and incubated for 10 min to solubilize the formazan crystals. The optical density is measured at 620 nm in an ELISA multi-well plate reader. The OD value is used to calculate the percentage of viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

2-Pyrrolidinone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.7509 mL 58.7544 mL 117.5088 mL 293.7720 mL
5 mM 2.3502 mL 11.7509 mL 23.5018 mL 58.7544 mL
10 mM 1.1751 mL 5.8754 mL 11.7509 mL 29.3772 mL
15 mM 0.7834 mL 3.9170 mL 7.8339 mL 19.5848 mL
20 mM 0.5875 mL 2.9377 mL 5.8754 mL 14.6886 mL
25 mM 0.4700 mL 2.3502 mL 4.7004 mL 11.7509 mL
30 mM 0.3917 mL 1.9585 mL 3.9170 mL 9.7924 mL
40 mM 0.2938 mL 1.4689 mL 2.9377 mL 7.3443 mL
50 mM 0.2350 mL 1.1751 mL 2.3502 mL 5.8754 mL
60 mM 0.1958 mL 0.9792 mL 1.9585 mL 4.8962 mL
80 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
100 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9377 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Pyrrolidinone616-45-52-Pyrrolidone2-吡咯烷酮Endogenous MetaboliteInhibitorinhibitorinhibit

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