2-Acetylfuran-d₃  (Synonyms: 乙酰呋喃-d₃; 2-Furyl methyl ketone-d₃)

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na⁺/K⁺-ATPase whereas in microsomes, both Na⁺/K⁺-ATPase and Mg²⁺-ATPase activities are significantly stimulated in a dose-dependent manner^[1]. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells^[2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

113.13

C₆H₃D₃O₂

2-乙酰呋喃-d₃；乙酰呋喃-d₃； 2-乙酰基呋喃-d₃；2-呋喃基甲基甲酮-d₃；2-呋喃基甲基酮-d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Wang Y, et al. Amino acid-dependent formation pathways of 2-acetylfuran and 2,5-dimethyl-4-hydroxy-3[2H]-furanone in the Maillard reaction. Food Chemistry. 2009 Jul 1; 115(1):233-237.

  [3]. Banerjee R, et, al. Medicinal significance of furan derivatives: A Review . International Journal of Research in Phytochemistry and Pharmacology. 2015, 5(3):48-57.