2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. 2-Hydroxysaclofen

2-Hydroxysaclofen 

目录号: HY-100812 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

2-Hydroxysaclofen 是一种有效的 γ 氨基丁酸转氨酶 B (GABAB) 受体拮抗剂。2-Hydroxysaclofen 可消除尼古丁诱导的低运动效应，增加其镇痛作用。2-Hydroxysaclofen 可刺激雌性大鼠促黄体生成素 (LH) 分泌。

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2-Hydroxysaclofen Chemical Structure

2-Hydroxysaclofen Chemical Structure

CAS No. : 117354-64-0

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规格 价格 是否有货 数量
1 mg ￥1100
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Customer Review

2-Hydroxysaclofen 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats[1][2][3].

IC50 & Target

GABAB receptor[1]
体内研究
(In Vivo)

2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)[1]
Dosage: 0.25, 0.5 and 1 mg/kg
Administration: IP; single dosage; after 10 or 45 min of nicotine administration
Result: Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg.
Animal Model: Male Wistar rats[2]
Dosage: 0.3, 1 and 3 mg/kg
Administration: IP; single dosage
Result: Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue.
Animal Model: Female Wistar rats (8 weeks)[3]
Dosage: 0, 20, 50 or 100 μg/2 μL
Administration: ICV; single dosage
Result: Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection.
The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg.
分子量

265.71

Formula

C9H12ClNO4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (188.18 mM; ultrasonic and adjust pH to 11 with 1 M NaOH)

1M NaOH 中的溶解度 : 26.57 mg/mL (100.00 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7635 mL 18.8175 mL 37.6350 mL
5 mM 0.7527 mL 3.7635 mL 7.5270 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

2-Hydroxysaclofen 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
1M NaOH / H2O 1 mM 3.7635 mL 18.8175 mL 37.6350 mL 94.0875 mL
5 mM 0.7527 mL 3.7635 mL 7.5270 mL 18.8175 mL
10 mM 0.3764 mL 1.8818 mL 3.7635 mL 9.4088 mL
15 mM 0.2509 mL 1.2545 mL 2.5090 mL 6.2725 mL
20 mM 0.1882 mL 0.9409 mL 1.8818 mL 4.7044 mL
25 mM 0.1505 mL 0.7527 mL 1.5054 mL 3.7635 mL
30 mM 0.1255 mL 0.6273 mL 1.2545 mL 3.1363 mL
40 mM 0.0941 mL 0.4704 mL 0.9409 mL 2.3522 mL
50 mM 0.0753 mL 0.3764 mL 0.7527 mL 1.8818 mL
60 mM 0.0627 mL 0.3136 mL 0.6273 mL 1.5681 mL
80 mM 0.0470 mL 0.2352 mL 0.4704 mL 1.1761 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Hydroxysaclofen117354-64-0GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorNicotinehypolocomotorantinociceptiveluteinizing hormoneInhibitorinhibitorinhibit

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