2. GPCR/G Protein Neuronal Signaling NF-κB TGF-beta/Smad Stem Cell/Wnt
  3. GPR119 NF-κB TGF-beta/Smad GLP Receptor
  4. 2-Oleoylglycerol

2-Oleoylglycerol  (Synonyms: 2-十八烯酸单甘油酯; 2-OG)

目录号: HY-W011121 纯度: ≥99.0%
COA 产品使用指南 技术支持

2-Oleoylglycerol (2-OG) 是饮食中存在的脂质。2-Oleoylglycerol 是一种 GPR119 激动剂，在瞬时转染的 COS-7 细胞中激活 hGPR119 的 EC50 值为 2.5 μM。2-Oleoylglycerol 通过激活 GPR119/TAK1/NF-κB/TGF-β1 信号通路，增强巨噬细胞的炎症反应，促进纤维化的发生。2-Oleoylglycerol 还可以在体内刺激胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 有望用于非酒精性脂肪性肝炎疾病的研究。

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2-Oleoylglycerol Chemical Structure

2-Oleoylglycerol Chemical Structure

CAS No. : 3443-84-3

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2-Oleoylglycerol 相关抗体

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  • 生物活性

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生物活性

2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) [1][2][3].

IC50 & Target

IC50: 2.5 μM (hGPR119) (in COS-7 cells)[1]
体外研究
(In Vitro)

2-Oleoylglycerol (50 μg/mL，24 小时) 通过 GPR119/TAK1/NF-κB/TGF-β1 信号通路激活 RAW264.7 细胞[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Oleoylglycerol 相关抗体:

Real Time qPCR[3]

Cell Line: Mouse RAW264.7 macrophage cells
Concentration: 50 μg/mL
Incubation Time: 24 hours
Result: Increased expression of GPR119, TGF-β1, IL-1β, and TNF-α, enhancing the gene expression of HSC activation.
体内研究
(In Vivo)

2-Oleoylglycerol (20 μg/小鼠，溶解于0.2 mL PBS，静脉注射，每周三次，持续 6 周) 通过促进肝脏巨噬细胞 (MΦ) 中 TGF-β1 的产生，在非酒精性脂肪性肝炎 (NASH) 模型中诱导肝纤维化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice, CL-HFS-induced non-alcoholic steatohepatitis (NASH) model[3]
Dosage: 20 μg/mouse in 0.2 mL PBS
Administration: Intravenous administration (I.V.), three times a week for 6 weeks
Result: Showed increased hepatic infiltration of inflammatory cells, increased collagen and α-SMA production; 2-OG enhanced liver resident MΦ and HSC activation.
分子量

356.55

Formula

C21H40O4
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

2-十八烯酸单甘油酯；2-甘油单油酸酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (279 KB)

产品使用指南 (1538 KB)
参考文献

2-Oleoylglycerol 相关分类

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Keywords:

2-Oleoylglycerol3443-84-32-OG2-十八烯酸单甘油酯2-甘油单油酸酯GPR119NF-κBTGF-beta/SmadGLP ReceptorG Protein-Coupled Receptor 119Nuclear factor-κBNuclear factor-kappaBTransforming growth factor betalipidCOS-7glucagon-likepeptide-1GLP-1Inhibitorinhibitorinhibit

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