1. Anti-infection
  2. Bacterial
  3. 22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin 

目录号: HY-146756
产品使用指南

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) 是一种抗细菌 (antibacterial) 的 pleuromutilin 衍生物,对 Gram-positive pathogens (GPPs) 和 Mycoplasma pneumoniae 具有抗菌效果。

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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Chemical Structure

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Chemical Structure

CAS No. : 2780409-77-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae[1].

体外研究
(In Vitro)

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 µg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 µg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 µg/mL, 72 h) shows low cytotoxicity in human cancer cells[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Five human cancer cell lines (HeG2, U87, HGC27, HT29 and MCF2)
Concentration: 0-10 µg/mL
Incubation Time: 72 h
Result: Showed low cytotoxicity ((IC50>10 μmol/L).
分子量

526.66

Formula

C30H42N2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin
目录号:
HY-146756
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