2. Apoptosis
  3. Apoptosis
  4. 27-TBDMS-4-Dehydrowithaferin A

27-TBDMS-4-Dehydrowithaferin A 是一种叶黄素 A 衍生物，对肿瘤细胞具有强大的抗增殖作用。27-TBDMS-4-Dehydrowithaferin A 诱导肿瘤细胞凋亡。27-TBDMS-4-Dehydrowithaferin A 是一种抗癌剂。

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27-TBDMS-4-Dehydrowithaferin A Chemical Structure

27-TBDMS-4-Dehydrowithaferin A Chemical Structure

CAS No. : 1214886-31-3

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规格 价格 是否有货 数量
1 mg ￥1706
3 - 4 周
5 mg   询价  
10 mg   询价  

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27-TBDMS-4-Dehydrowithaferin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
17 nM
Compound: 22
Antiproliferative activity against cisplatin-sensitive human A2780 cells measured after 96 hrs by MTT assay
Antiproliferative activity against cisplatin-sensitive human A2780 cells measured after 96 hrs by MTT assay
[PMID: 31008605]
A549 IC50
2.9 μM
Compound: 9b
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
A549 IC50
5.3 μM
Compound: 9b
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
ARPE-19 IC50
1660 nM
Compound: 22
Cytotoxicity against human ARPE19 cells measured after 96 hrs by MTT assay
Cytotoxicity against human ARPE19 cells measured after 96 hrs by MTT assay
[PMID: 31008605]
HeLa IC50
1.7 μM
Compound: 9b
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
HeLa IC50
2.1 μM
Compound: 9b
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
MCF7 IC50
0.2 μM
Compound: 9b
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
MCF7 IC50
0.5 μM
Compound: 9b
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
Vero IC50
3.1 μM
Compound: 9b
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
Vero IC50
4 μM
Compound: 9b
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
体外研究
(In Vitro)

27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC50=1.7 μM), A-549 (IC50=5.3 μM), MCF-7 (IC50=0.5 μM), and normal Vero cells (IC50=3.1 μM)[1].
27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells[1].
27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

27-TBDMS-4-Dehydrowithaferin A 相关抗体:
分子量

582.84

Formula

C34H50O6Si
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

27-TBDMS-4-Dehydrowithaferin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

27-TBDMS-4-Dehydrowithaferin A1214886-31-3Apoptosiswithaferin Aantiproliferative effectHeLaA-549MCF-7VeroInhibitorinhibitorinhibit

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