2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide 

目录号: HY-152604
产品使用指南

摩尔计算器

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。

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3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide Chemical Structure

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide Chemical Structure

CAS No. : 356782-84-8

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规格 价格 是否有货 数量
5 mg ￥488
1 - 2 周
10 mg   询价  
50 mg   询价  

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3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CV-1 EC50
> 100 μg/mL
Compound: T-1106
Antiviral activity against YFV infected in african green monkey CV1 cells assessed as reduction in cytopathic effect after 6 days
Antiviral activity against YFV infected in african green monkey CV1 cells assessed as reduction in cytopathic effect after 6 days
[PMID: 17420215]
MDCK CC50
> 250 μM
Compound: T-1105-ribonucleoside
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay
[PMID: 29906392]
MDCK CC50
> 250 μM
Compound: T-1105-ribonucleoside
Cytotoxicity against HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay
Cytotoxicity against HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in cell viability after 3 days by formazan-based MTS assay
[PMID: 29906392]
Vero EC50
> 100 μg/mL
Compound: T-1106
Antiviral activity against YFV infected in african green monkey Vero cells assessed as reduction in cytopathic effect after 6 days
Antiviral activity against YFV infected in african green monkey Vero cells assessed as reduction in cytopathic effect after 6 days
[PMID: 17420215]
Vero CC50
> 4000 μM
Compound: T-1106
Cytotoxicity against African green monkey Vero cells by luciferase-based cell viability assay
Cytotoxicity against African green monkey Vero cells by luciferase-based cell viability assay
[PMID: 18955536]
Vero EC50
1080 μM
Compound: T-1106
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by microscopic analysis
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by microscopic analysis
[PMID: 18955536]
Vero EC50
1800 μM
Compound: T-1106
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 2 hrs by NR dye uptake assay
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect after 2 hrs by NR dye uptake assay
[PMID: 18955536]
Vero EC50
2630 μM
Compound: T-1106
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by luciferase reporter gene assay
Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by luciferase reporter gene assay
[PMID: 18955536]
分子量

271.23

Formula

C10H13N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide356782-84-8Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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