2. PI3K/Akt/mTOR
  3. PIN1
  4. 3-Pyridine toxoflavin

3-Pyridine toxoflavin (compound 49) 是一种 PIN1 抑制剂。3-Pyridine toxoflavin 可用于免疫疾病增生障碍的研究。

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3-Pyridine toxoflavin Chemical Structure

3-Pyridine toxoflavin Chemical Structure

CAS No. : 32502-20-8

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3-Pyridine toxoflavin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.3 μM
Compound: 4j
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
[PMID: 31784197]
HepG2 IC50
1.8 μM
Compound: 4j
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
[PMID: 31784197]
体外研究
(In Vitro)

3-Pyridine toxoflavin 对 PIN1 的高通量筛选 (HTS) 平均效能为 25 μM，抑制率为 48%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Pyridine toxoflavin 相关抗体:
分子量

270.25

Formula

C12H10N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Pyridine toxoflavin 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Pyridine toxoflavin32502-20-8PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1proliferative disorderimmune diseaseInhibitorinhibitorinhibit

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