2. Apoptosis
  3. Apoptosis
  4. 4-(Dodecylamino)phenol

4-(Dodecylamino)phenol  (Synonyms: p-DDAP; p-Dodecylaminophenol)

目录号: HY-131724
产品使用指南

摩尔计算器

4-(Dodecylamino)phenol (p-DDAP) 是一种抗癌剂。4-(Dodecylamino)phenol 具有抗肿瘤活性，可抑制增殖、阻滞细胞周期并诱导凋亡细胞死亡。4-(Dodecylamino)phenol 可用于前列腺癌等癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4-(Dodecylamino)phenol Chemical Structure

4-(Dodecylamino)phenol Chemical Structure

CAS No. : 25848-37-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

4-(Dodecylamino)phenol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-1080 IC50
> 10 μM
Compound: 1, 4-(dodecylamino)phenol
Reduction of proMMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
Reduction of proMMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
[PMID: 23953690]
HT-1080 IC50
0.7 μM
Compound: 1, 4-(dodecylamino)phenol
Reduction of MMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
Reduction of MMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
[PMID: 23953690]
HT-1080 IC50
0.9 μM
Compound: 1, 4-(dodecylamino)phenol
Reduction of proMMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
Reduction of proMMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
[PMID: 23953690]
HT-1080 IC50
1 μM
Compound: 1, 4-(dodecylamino)phenol
Cytotoxicity against human HT1080 cells assessed as growth inhibition after 72 hrs by trypan blue dye exclusion assay
Cytotoxicity against human HT1080 cells assessed as growth inhibition after 72 hrs by trypan blue dye exclusion assay
[PMID: 23953690]
HT-1080 IC50
2.4 μM
Compound: 1, 4-(dodecylamino)phenol
Reduction of MMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
Reduction of MMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis
[PMID: 23953690]
HuCCT-1 IC50
2 μM
Compound: 1
Cytotoxicity against human HuCCT1 cells after 72 hrs by MTT assay
Cytotoxicity against human HuCCT1 cells after 72 hrs by MTT assay
[PMID: 22440084]
MIA PaCa-2 IC50
10 μM
Compound: 1
Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 22440084]
体外研究
(In Vitro)

4-(Dodecylamino)phenol (p-DDAP) (0-10 μM; 72 h) induces growth arrest in NB-39-nu cells[1].
p-DDAP (0.1, 0.2, 0.4, 10 μM; ) arrestes the cell cycle in the G0/G1 phase in dose-dependent manner[1].
p-DDAP (0.2 μM; 48 h) induces apoptotosis without differentiation[1].
p-DDAP (0.2, 0.4, 1 μM; 24 h, 72 h) induces apoptotic cell death through bcl-2 down-regulation and caspases activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-(Dodecylamino)phenol 相关抗体:

Cell Proliferation Assay[1]

Cell Line: NB-39-nu cells
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Showed potent growth inhibitory effects against NB-39-nu cells.

Cell Cycle Analysis[1]

Cell Line: NB-39-nu cells
Concentration: 0.1, 0.2, 0.4, 10 μM
Incubation Time: 24 h
Result: Induced G0/G1-phase arrest in NB-39-nucells.

Apoptosis Analysis[1]

Cell Line: NB-39-nu cells
Concentration: 0.2 μM
Incubation Time: 48 h
Result: Induced G0/G1-phase arrest, displayed morphological apoptotic features, including aggregation and nuclear fragmentation in NB-39-nu cells.
体内研究
(In Vivo)

4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen-free athymic BALB/c nu/nu nude mice (6 weeks of age, male)[2]
Dosage: 10, 15, 40 mg/kg
Administration: i.v., daily, for 2 weeks or i.p., single
Result: Suppressed tumor growth in PC-3-implanted mice in vivo.
分子量

277.44

Formula

C18H31NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-(Dodecylamino)phenol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(Dodecylamino)phenol25848-37-7p-DDAP p-DodecylaminophenolApoptosisanti-tumoranticancerproliferationcell cycleapoptoticprostate cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
4-(Dodecylamino)phenol
目录号：
HY-131724
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z