2. Apoptosis
  3. MDM-2/p53 Bcl-2 Family Apoptosis
  4. 4-Hydroxyresveratrol

4-Hydroxyresveratrol  (Synonyms: 4-羟基白藜芦醇; 3,4,5,4'-Tetrahydroxystibene)

目录号: HY-126311
产品使用指南 技术支持

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) 是白藜芦醇 (HY-16561) 类似物，能不同程度地诱导促凋亡的 p53/Bax 基因表达。4-Hydroxyresveratrol 可诱导 SV40 病毒转化的 WI38 细胞 (WI38VA) 细胞凋亡，但不诱导 WI38 细胞凋亡。4-Hydroxyresveratrol 可显著诱导WI38VA 中 p53、GADD45 和 Bax 基因的表达，同时抑制 bcl-2 基因的表达。

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4-Hydroxyresveratrol Chemical Structure

4-Hydroxyresveratrol Chemical Structure

CAS No. : 331443-00-6

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4-Hydroxyresveratrol 相关抗体

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查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

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  • 参考文献

生物活性

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA[1].

IC50 & Target[1]

Bax

 

分子量

244.24

Formula

C14H12O4
CAS 号
中文名称

4-羟基白藜芦醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Hydroxyresveratrol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

4-Hydroxyresveratrol331443-00-63,4,5,4'-Tetrahydroxystibene4-羟基白藜芦醇MDM-2/p53Bcl-2 FamilyApoptosispro-apoptoticSV40WI38 cellsWI38VAGADD45Baxbcl-2Inhibitorinhibitorinhibit

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