2. 天然产物
  3. 黄酮类 内源性代谢物
  4. 黄酮
  5. 4'-Methoxyflavone

4'-Methoxyflavone 是一种黄酮类化合物，具有抗氧化性和对癌细胞的抗增殖活性。4'-Methoxyflavone 可以抑制细胞周期依赖性激酶导致细胞周期停滞，调节细胞信号传导途径来影响细胞增殖和凋亡。4'-Methoxyflavone 可用于癌症化学预防的研究。

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4'-Methoxyflavone Chemical Structure

4'-Methoxyflavone Chemical Structure

CAS No. : 4143-74-2

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4'-Methoxyflavone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. 4'-Methoxyflavone can inhibit cycle-dependent kinases leading to cell cycle arrest and regulate cell signaling pathways to influence cell proliferation and apoptosis. 4'-Methoxyflavone can be used in cancer chemoprevention research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BTI-TN-5B1-4 IC50
27.87 μM
Compound: 3d
Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay
Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay
[PMID: 20045650]
MCF7 GI50
61.8 μM
Compound: 1e
Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay
10.1007/s00044-012-0423-1
MDCK CC50
191.8 μM
Compound: 1f
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay
[PMID: 31744778]
MDCK EC50
9.36 nM
Compound: 1f
Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay
Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay
[PMID: 31744778]
MOLT-4 GI50
99.2 μM
Compound: 1e
Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) MOLT4 cells after 48 hr by SRB assay
10.1007/s00044-012-0423-1
分子量

252.26

Formula

C16H12O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4'-Methoxyflavone 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

4'-Methoxyflavone4143-74-2Othersflavonoidantioxidantanti-proliferationcell cycleInhibitorinhibitorinhibit

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