2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 5β-Androstan-3β-ol-17-one

5β-Androstan-3β-ol-17-one  (Synonyms: 3β-Etiocholanolone; 5β-Epiandrosterone)

目录号: HY-113349
产品使用指南

摩尔计算器

5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone) 是一种 5β 还原的类固醇，是脱氢表雄酮 (DHEA) 的主要代谢产物之一。5β-Androstan-3β-ol-17-one 对 C57BL/KsJ 基因糖尿病 (db/db) 小鼠具有较强的降糖作用。5β-Androstan-3β-ol-17-one 也表现出神经元的抑制作用。

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5β-Androstan-3β-ol-17-one Chemical Structure

5β-Androstan-3β-ol-17-one Chemical Structure

CAS No. : 571-31-3

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5β-Androstan-3β-ol-17-one 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2].

体内研究
(In Vivo)

5β-Androstan-3β-ol-17-one (2 mg/mouse; 皮下注射; 每天 1 次, 共 4 周) 缺乏任何有益的影响，这表明这些代谢物需要一些生物转化才能完全有效[1]。
5β-Androstan-3β-ol-17-one (添加饲料中, 质量比分别为 0.025%, 0.05%, 0.1%; 口服; 共 18 周) 在小鼠中，防止严重糖尿病的发生，调节高血糖状态正常化，同时对进食量或体重增加率无影响[1]。
5β-Androstan-3β-ol-17-one (1 mg/kg-20 mg/kg; 静脉注射; 单剂量) 在高剂量下，对成年公猫的神经元有强烈的抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/KsJ genetically diabetic (db/db) mice model[1]
Dosage: 0.025%, 0.05%, 0.1% in diet
Administration: Oral gavage; filled the diet every second day; for 18 weeks
Result: Exerted strong antihyperglycemic effects.
分子量

290.44

Formula

C19H30O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5β-Androstan-3β-ol-17-one 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5β-Androstan-3β-ol-17-one571-31-33β-Etiocholanolone 5β-EpiandrosteroneEndogenous MetaboliteC57BL/KsJ genetically diabetic (db/db) miceInhibitorinhibitorinhibit

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