2. PROTAC
  3. PROTAC Linkers
  4. 5-endo-BCN-pentanoic acid

5-endo-BCN-pentanoic acid 

目录号: HY-140350 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

5-endo-BCN-pentanoic acid 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。5-endo-BCN-pentanoic acid 是一种点击化学试剂。它含有 BCN 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。

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5-endo-BCN-pentanoic acid Chemical Structure

5-endo-BCN-pentanoic acid Chemical Structure

CAS No. : 2364591-80-8

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规格 价格 是否有货 数量
5 mg ￥800
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10 mg ￥1280
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25 mg ￥2560
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5-endo-BCN-pentanoic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-endo-BCN-pentanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 5-endo-BCN-pentanoic acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-endo-BCN-pentanoic acid 相关抗体:
分子量

293.36

Formula

C16H23NO4
CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (282 KB) HNMR (136 KB)

产品使用指南 (1538 KB)
参考文献

5-endo-BCN-pentanoic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-endo-BCN-pentanoic acid2364591-80-8PROTAC LinkersInhibitorinhibitorinhibit

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