2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 5α-Hydroxy-6-keto cholesterol

5α-Hydroxy-6-keto cholesterol  (Synonyms: 5α-羟基-6-酮胆固醇)

目录号: HY-123349
产品使用指南 技术支持

5α-Hydroxy-6-keto cholesterol 是 β-epoxide (5α,6β-epoxycholesterol) 在完整培养的人支气管上皮细胞 (16-HBE) 直接暴露于臭氧期间的主要代谢物。5α-Hydroxy-6-keto cholesterol 抑制胆固醇 (cholesterol) 合成，IC50 为 350 nM。

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5α-Hydroxy-6-keto cholesterol Chemical Structure

5α-Hydroxy-6-keto cholesterol Chemical Structure

CAS No. : 13027-33-3

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规格 价格 是否有货 数量
5 mg ￥3067
3 - 4 周
10 mg   询价  
50 mg   询价  

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5α-Hydroxy-6-keto cholesterol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ARPE-19 IC50
33.9 μM
Compound: 3
Cytotoxicity against human ARPE19 cells assessed as cell viability after 48 hrs by alamar blue assay
Cytotoxicity against human ARPE19 cells assessed as cell viability after 48 hrs by alamar blue assay
[PMID: 21797280]
HEK293 EC50
1.7 μM
Compound: 7
Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
[PMID: 24928400]
HT-29 IC50
17 μM
Compound: 3
Cytotoxicity against human HT-29 cells assessed as cell viability after 48 hrs by alamar blue assay
Cytotoxicity against human HT-29 cells assessed as cell viability after 48 hrs by alamar blue assay
[PMID: 21797280]
HT-29 IC50
17 μM
Compound: 5
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay
[PMID: 20931970]
体外研究
(In Vitro)

5α-Hydroxy-6-keto cholesterol (0.01, 0.1, 1, 10 μM) is cytotoxic to cultured 16-HBE cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5α-Hydroxy-6-keto cholesterol 相关抗体:
分子量

418.65

Formula

C27H46O3
CAS 号
中文名称

5α-羟基-6-酮胆固醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5α-Hydroxy-6-keto cholesterol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5α-Hydroxy-6-keto cholesterol13027-33-35α-羟基-6-酮胆固醇Drug Metabolite16-HBEβ-epoxide5α,6β-epoxycholesterolcholesterolInhibitorinhibitorinhibit

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