2. Neuronal Signaling
  3. Amyloid-β
  4. 6′-Methyl paeonol

6’-Methyl paeonol 是一种丹皮酚衍生物，可抑制异常去极化并减少 Amyloid-β 诱导的 ERK 磷酸化。6’-Methyl paeonol 可以缓解阿兹海默症。

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6′-Methyl paeonol Chemical Structure

6′-Methyl paeonol Chemical Structure

CAS No. : 6540-66-5

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6′-Methyl paeonol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6’-Methyl paeonol is a paeonol derivative, which inihibits abnormal depolarizations and reduces the Amyloid β-induced ERK phosphorylation. 6’-Methyl paeonol exhibits alleviating activity against Alzheimer’s Disease[1].

体外研究
(In Vitro)

6’-Methyl paeonol (0.1-100 μM) inhibits the NMDA- and AMPA-induced neuronal depolarization, and thereby ameliorates the Aβ-induced abnormal depolarization.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6′-Methyl paeonol 相关抗体:

Western Blot Analysis[1]

Cell Line: C2C12
Concentration: 100 μM
Incubation Time: 2 h
Result: Reversed the increase of ERK phosphorylation induced by Aβ
体内研究
(In Vivo)

6’-Methyl paeonol (20 mg/kg，皮下注射) 可改善 J20 小鼠的记忆和学习损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP transgenic C57BL/6 mice (J20 mice)[1]
Dosage: 20 mg/kg
Administration: subcutaneous injection
Result: Reduced the time for mice reaching hidden platform.
分子量

180.20

Formula

C10H12O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6′-Methyl paeonol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6′-Methyl paeonol6540-66-5Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s diseaseERKMorris Water MazeInhibitorinhibitorinhibit

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