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  4. 6α-Chloro-5β-hydroxywithaferin A

6α-Chloro-5β-hydroxywithaferin A 是一种睡茄内酯类化合物，可以从 W. somnifera 中提取得到。W. somnifera 具有抗氧化、抗炎、免疫调节、抗癌、抗菌、抗帕金森和抗应激特性。

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6α-Chloro-5β-hydroxywithaferin A Chemical Structure

6α-Chloro-5β-hydroxywithaferin A Chemical Structure

CAS No. : 52329-20-1

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规格 价格 是否有货 数量
1 mg ￥1440
1 - 2 周
5 mg ￥3520
1 - 2 周
10 mg   询价  
50 mg   询价  

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6α-Chloro-5β-hydroxywithaferin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
14.7 μM
Compound: 56
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
A549 IC50
14.7 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
A549 IC50
16.1 μM
Compound: 56
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
A549 IC50
8.6 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
HeLa IC50
12.1 μM
Compound: 17
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
HeLa IC50
13.4 μM
Compound: 56
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
HeLa IC50
13.4 μM
Compound: 17
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
HeLa IC50
17.5 μM
Compound: 56
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
MCF7 IC50
1.3 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
MCF7 IC50
7.5 μM
Compound: 56
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
MCF7 IC50
7.5 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
MCF7 IC50
7.9 μM
Compound: 56
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
Vero IC50
14.8 μM
Compound: 56
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
Vero IC50
14.8 μM
Compound: 17
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 22705001]
Vero IC50
7.8 μM
Compound: 56
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
[PMID: 28923386]
Vero IC50
7.8 μM
Compound: 17
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 22705001]
分子量

507.06

Formula

C28H39ClO6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6α-Chloro-5β-hydroxywithaferin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6α-Chloro-5β-hydroxywithaferin A52329-20-1BacterialwithanolideWithaniasomniferaInhibitorinhibitorinhibit

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