2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 

目录号: HY-113969
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摩尔计算器

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11)，四氢异喹啉 (THIQ) 衍生物，是一种选择性的苯乙醇胺 N-甲基转移酶 (PNMT) 抑制剂，其 Ki 值为 0.3 μM。7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 可用于阿尔茨海默病和帕金森病等相关精神疾病的研究。

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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Chemical Structure

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Chemical Structure

CAS No. : 61563-24-4

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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].

体内研究
(In Vivo)

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2]
Dosage: 40 mg/kg
Administration: i.p.; once daily; 3 days
Result: Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.
Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
分子量

202.08

Formula

C9H9Cl2N
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 相关分类

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Keywords:

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline61563-24-4Endogenous MetabolitetetrahydroisoquinolineTHIQ derivativePNMTAlzheimer's diseaseParkinson's diseaseInhibitorinhibitorinhibit

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