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  4. 7,9-Dimethylguanine

7,9-Dimethylguanine  (Synonyms: 7,9-二甲基鸟嘌呤)

目录号: HY-W439487
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7,9-Dimethylguanine是一种修饰的核苷酸碱基，其在酒精性肝病（ALD）患者的尿液和血清中含量与ALD的严重程度密切相关。通过无目标和非目标代谢组学方法对ALD患者和对照组的尿液和血清样本中的自由核苷酸/碱基进行提取和定量，发现尿液中有39种自由核苷酸/碱基，血清中有40种，其中12种和11种修饰的核苷酸碱基在患者样本中显著变化（q < 0.05 和 fold-change > 20%）。7,9-Dimethylguanine在尿液中的含量和2-甲基硫代-N6-丝氨酸氨甲酰腺苷（ms2t6A）在血清中的含量与ALD的严重程度有很强的关联，其与Model for End-stage Liver Disease (MELD)评分的Spearman等级相关系数分别为0.66和0.74。值得注意的是，这两种代谢物的含量变化足够大，可以区分严重的酒精性肝炎（AH）与非严重的ALD，以及非严重的ALD与健康对照。

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7,9-Dimethylguanine Chemical Structure

7,9-Dimethylguanine Chemical Structure

CAS No. : 524-35-6

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7,9-Dimethylguanine 相关抗体

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生物活性

7,9-Dimethylguanine is a modified nucleotide base whose content in urine and serum of patients with alcoholic liver disease (ALD) is closely related to the severity of ALD. The free nucleotides/bases in urine and serum samples of ALD patients and controls were extracted and quantified by untargeted and nontargeted metabolomics methods, and 39 free nucleotides/bases were found in urine and 40 in serum, of which 12 and 11 modified nucleotide bases were significantly changed in patient samples (q < 0.05 and fold-change > 20%). The content of 7,9-Dimethylguanine in urine and 2-methylthio-N6-serine carbamoyl adenosine (ms2t6A) in serum were strongly associated with the severity of ALD, with Spearman rank correlation coefficients of 0.66 and 0.74 with Model for End-stage Liver Disease (MELD) scores, respectively. Notably, the levels of these two metabolites varied sufficiently to distinguish severe alcoholic hepatitis (AH) from non-severe ALD, and non-severe ALD from healthy controls.

分子量

179.18

Formula

C7H9N5O
CAS 号
中文名称

7,9-二甲基鸟嘌呤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7,9-Dimethylguanine 相关分类

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Keywords:

7,9-Dimethylguanine524-35-67,9-二甲基鸟嘌呤OthersInhibitorinhibitorinhibit

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