2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 7-Hydroxymethotrexate

7-Hydroxymethotrexate  (Synonyms: 7-羟基甲氨蝶呤)

目录号: HY-130569
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摩尔计算器

7-Hydroxymethotrexate 是 Methotrexate (MTX; HY-14519) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂，可以抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。

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7-Hydroxymethotrexate Chemical Structure

7-Hydroxymethotrexate Chemical Structure

CAS No. : 5939-37-7

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Other Forms of 7-Hydroxymethotrexate:

7-Hydroxymethotrexate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

体外研究
(In Vitro)

7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7-Hydroxymethotrexate 相关抗体:
体内研究
(In Vivo)

7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (270-440 g)[1]
Dosage: 4 mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg.
分子量

470.44

Formula

C20H22N8O6
CAS 号
中文名称

7-羟基甲氨蝶呤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Hydroxymethotrexate 相关分类

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Keywords:

7-Hydroxymethotrexate5939-37-77-羟基甲氨蝶呤Drug MetaboliteMethotrexateMTXantimetaboliteantifolateenzymedihydrofolatereductasetetrahydrofolateDNAsynthesisInhibitorinhibitorinhibit

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