2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Angiotensin II (3-8), human

Angiotensin II (3-8), human 是一种活性稍弱的血管紧张素 AT1 受体激动剂。

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Custom Peptide Synthesis

Angiotensin II (3-8), human Chemical Structure

Angiotensin II (3-8), human Chemical Structure

CAS No. : 12676-15-2

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Angiotensin II (3-8), human 的其他形式现货产品:

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Angiotensin II (3-8), human 相关抗体

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查看 Angiotensin Receptor 亚型特异性产品:

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

IC50 & Target

Angiotensin AT1 receptor[1]
体内研究
(In Vivo)

Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

774.91

Formula

C40H54N8O8
CAS 号
Sequence

Val-Tyr-Ile-His-Pro-Phe
Sequence Shortening

VYIHPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats[1]
Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Angiotensin II (3-8), human 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Angiotensin II (3-8), human12676-15-2Angiotensin ReceptorInhibitorinhibitorinhibit

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目录号：
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