2. Epigenetics
  3. Histone Demethylase
  4. CBB1007

CBB1007可渗透入细胞，是hLSD1的选择性抑制剂，IC50为5.27 μM。

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CBB1007 Chemical Structure

CBB1007 Chemical Structure

CAS No. : 1379573-92-8

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CBB1007 的其他形式现货产品:

Other Forms of CBB1007:

CBB1007 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

WB

    CBB1007 purchased from MCE. Usage Cited in: BMC Neurosci. 2022 Nov 10;23(1):63.  [Abstract]

    CBB1007 (CBB) elevates H3K4me2 expression in RGC-5 cells, after which miR-21-5p expression levels are increased .

    查看 Histone Demethylase 亚型特异性产品:

    查看所有亚型
    KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). IC50 Value: 5.27 uM Target: hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM). CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM).

    分子量

    534.61

    Formula

    C27H34N8O4
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    CBB1007 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CBB10071379573-92-8CBB 1007CBB-1007Histone DemethylaseInhibitorinhibitorinhibit

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    目录号：
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