2. Anti-infection
  3. SARS-CoV
  4. Casirivimab

Casirivimab  (Synonyms: 卡西瑞单抗; REGN10933)

目录号: HY-P99341 纯度: ≥95.0%
COA

摩尔计算器

Casirivimab (REGN10933) 是一种人的单克隆抗体，靶向导致 COVID-19 的 SARS-CoV-2 病毒。Casirivimab 对 COVID-19 变种缺乏疗效。Casirivimab 可与 Imdevimab (HY-P99342) 联合使用，改变了 K18-hACE2 小鼠对 SARS-CoV-2 δ 型变异的肺反应，有效降低病毒载量，改善病症。

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CAS No. : 2415933-42-3

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1 mg ￥3500
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5 mg ￥9100
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Casirivimab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

SARS-CoV-2[1]
体内研究
(In Vivo)

Casirivimab (400 μg (Casirivimab 和 imdevimab)，腹腔注射，单次剂量) 与 imdevimab 的联合使用在对抗 δ 变异株方面表现出了积极的效果，但在应对 Omicron 变异株时则显示出减弱的抗病毒能力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: K18-hACE2 mice vaccinated with the SARS-CoV-2 δ or Omicron variant[2]
Dosage: 400μg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Decreased amount of subgenomic E RNA (sgE RNA), which reduced the viral load and improved lung pathology in δ. Weakened antiviral effectiveness in the body against Omicron.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

卡西瑞单抗；卡西瑞单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: ≥95.0%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Casirivimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Casirivimab2415933-42-3REGN10933卡西瑞单抗REGN 10933REGN-10933SARS-CoVSARS coronavirusAntiviralviral loadInhibitorinhibitorinhibit

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