Chymase-IN-1 

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

IC50: 29 nM (chymase)^[1]

Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase K_i value of 36 nM and a Cat G K_i value of 9500 nM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t_1/2=1.8 h)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

431.83

C₂₀H₁₅ClNO₄PS

862090-74-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.  [Content Brief]