2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. ELN318463 racemate

ELN318463 racemate 是 ELN318463 的外消旋体。ELN318463 是淀粉样前体蛋白 (APP) 选择性的 γ-分泌酶 (γ-secretase) 抑制剂。ELN318463 对包含早老蛋白 (PS1) 和 PS2 的 γ-分泌酶抑制活性不同，对 PS1 和 PS2 的 EC50 分别为 12 nM 和 656 nM。ELN318463 对 PS1 的选择性比对 PS2 高约 51 倍。

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ELN318463 racemate Chemical Structure

ELN318463 racemate Chemical Structure

CAS No. : 851599-82-1

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规格 价格 是否有货
1 mg ￥2320
询问价格 & 货期
5 mg ￥5800
询问价格 & 货期
10 mg 现货 询问价格 & 货期

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Other Forms of ELN318463 racemate:

ELN318463 racemate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1[1][2].

IC50 & Target

γ-secretase[1]
体外研究
(In Vitro)

ELN318463 behaves as a classic γ-secretase inhibitor, demonstrates 75- to 120-fold selectivity for inhibiting Aβ production compared with Notch signaling in cells, and displaces an active site directed inhibitor at very high concentrations only in the presence of substrate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ELN318463 racemate 相关抗体:
体内研究
(In Vivo)

Brain levels of ELN318463 at 30 mg/kg are 0.754 μM in FVB brains and 0.69 μM in PDAPP brains, and at 100 mg/kg dose the levels were 2.7 μM in FVB brains and 1.87 μM in PDAPP brains. Discordance between Aβ1-40 and Aβx-40 in BACE KO or wild-type BACE inhibitor treated mice has been reported[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

471.80

Formula

C19H20BrClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ELN318463 racemate 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELN318463851599-82-1ELN 318463ELN-318463γ-secretaseGamma secretaseamyloidprecursorproteinAPPpresenilinPS1PS2AβNotchAlzheimerdiseaseInhibitorinhibitorinhibit

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产品名称：
ELN318463 racemate
目录号：
HY-50882A
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