2. MAPK/ERK Pathway Autophagy
  3. p38 MAPK Autophagy
  4. FR 167653 free base

FR 167653 free base 是具有口服活性的，选择性 p38 MAPK 抑制剂，通过特异性抑制 p38 MAPK 活性抑制 TNF-α 和 IL-1β 生成。FR 167653 free base 可用于体内炎症，减轻创伤和缺血/再灌注损伤。

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FR 167653 free base Chemical Structure

FR 167653 free base Chemical Structure

CAS No. : 158876-65-4

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FR 167653 free base 的其他形式现货产品:

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FR 167653 free base 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].

体内研究
(In Vivo)

FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred male Balbuc mice (aged 8 weeks)[1]
Dosage: 32 mg/kg
Administration: Subcutaneous injection; 24-48 hours
Result: The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.
分子量

427.43

Formula

C24H18FN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FR 167653 free base 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR 167653158876-65-4FR167653FR-167653p38 MAPKAutophagyInhibitorinhibitorinhibit

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