Imisopasem manganese (Synonyms: M40403; GC4403)

目录号: HY-13336 纯度: 98.15%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Imisopasem manganese (M40403) 是稳定的 MnSOD 的非肽基模拟物。

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Imisopasem manganese Chemical Structure

CAS No. : 218791-21-0

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规格	价格	是否有货
10 mM * 1 mL in Water	￥1097	In-stock
2 mg	￥550	In-stock
5 mg	￥997	In-stock
10 mg	￥1645	In-stock
25 mg	￥3450	In-stock
50 mg	￥5690	In-stock
100 mg	现货	询价
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

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MCE 顾客使用本产品发表的 2 篇科研文献

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD.

体外研究
(In Vitro)

Imisopasem 锰是一种小分子合成锰，含有超氧化物歧化酶模拟物 (SODm)，可去除超氧阴离子，而不会干扰已知参与炎症反应的其他活性物质 (例如一氧化氮、NO 和过氧亚硝酸盐、ONOO-)^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Imisopasem manganese 是一种小分子超氧化物歧化酶模拟物，已在动物模型疾病状态中显示出疗效，其中超氧阴离子被认为起着关键作用。Imisopasem manganese 抑制大鼠胸腔内注射角叉菜胶后的炎症反应。除 NOx、PGE2 和 IL-10 保持不变^[1] 外，Imisopasem 锰可减弱炎症的所有参数。Imisopasem 锰预处理小鼠的大肠细胞凋亡减少，尤其是小肠细胞凋亡减少，淋巴组织和造血组织显著恢复。Imisopasem manganese 可有效减少 TBI 引起的组织破坏，具有作为新型辐射防护剂的潜力^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

479.35

Formula

C₂₁H₃₁Cl₂MnN₅

CAS 号

218791-21-0

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

H₂O 中的溶解度 : 25 mg/mL (52.15 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0862 mL	10.4308 mL	20.8616 mL
5 mM	0.4172 mL	2.0862 mL	4.1723 mL
10 mM	0.2086 mL	1.0431 mL	2.0862 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 8.33 mg/mL (17.38 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 98.15%

选择批次：

Data Sheet (641 KB) SDS (393 KB)

COA (294 KB) RP-HPLC (245 KB) 元素分析报告 (216 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. [Content Brief]

[2]. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17. [Content Brief]

Animal Administration ^[1]^[2]	Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20 mg kg^-1), or an equivalent volume (0.3 mL) of vehicle (26 mm sodium bicarbonate buffer, pH 8.1-8.3), is injected intraperitoneally (i.p.) 15 min before carrageenan. At 4 h after the injection of carrageenan, the animals are killed by inhalation of CO₂^[1]. Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stock solution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested. In one, the dose of IR is held constant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30 mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receives 8.5 Gy total body irradiation (TBI). Control animals receives 0.1 ml of SBC buffer prior to TBI. In the other model, groups of 20 mice receives either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the other with SBC 30 min before TBI. All are followed for survival^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. [Content Brief] [2]. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17. [Content Brief]

Animal Administration
^[1]^[2]

Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20 mg kg^-1), or an equivalent volume (0.3 mL) of vehicle (26 mm sodium bicarbonate buffer, pH 8.1-8.3), is injected intraperitoneally (i.p.) 15 min before carrageenan. At 4 h after the injection of carrageenan, the animals are killed by inhalation of CO₂^[1].

Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stock solution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested. In one, the dose of IR is held constant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30 mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receives 8.5 Gy total body irradiation (TBI). Control animals receives 0.1 ml of SBC buffer prior to TBI. In the other model, groups of 20 mice receives either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the other with SBC 30 min before TBI. All are followed for survival^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. [Content Brief]

[2]. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17. [Content Brief]

Imisopasem manganese 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0862 mL	10.4308 mL	20.8616 mL	52.1540 mL
	5 mM	0.4172 mL	2.0862 mL	4.1723 mL	10.4308 mL
	10 mM	0.2086 mL	1.0431 mL	2.0862 mL	5.2154 mL
	15 mM	0.1391 mL	0.6954 mL	1.3908 mL	3.4769 mL
	20 mM	0.1043 mL	0.5215 mL	1.0431 mL	2.6077 mL
	25 mM	0.0834 mL	0.4172 mL	0.8345 mL	2.0862 mL
	30 mM	0.0695 mL	0.3477 mL	0.6954 mL	1.7385 mL
	40 mM	0.0522 mL	0.2608 mL	0.5215 mL	1.3038 mL
	50 mM	0.0417 mL	0.2086 mL	0.4172 mL	1.0431 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imisopasem manganese218791-21-0M40403 GC4403M 40403M-40403GC4403GC 4403GC-4403SODSuperoxide DismutaseInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Imisopasem manganese (Synonyms: M40403; GC4403)

Customer Review

MCE 顾客使用本产品发表的 2 篇科研文献