2. GPCR/G Protein Anti-infection
  3. Prostaglandin Receptor SARS-CoV
  4. KW-8232 free base

KW-8232 free base 

目录号: HY-100304 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

KW-8232 free base是一种具有口服活性的抗骨质疏松剂，可以减少前列腺素 PGE2 的生物合成。

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KW-8232 free base Chemical Structure

KW-8232 free base Chemical Structure

CAS No. : 170365-25-0

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规格 价格 是否有货 数量
1 mg ￥8500
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Customer Review

Other Forms of KW-8232 free base:

KW-8232 free base 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

IC50 & Target

Prostaglandin Receptor[1]
体外研究
(In Vitro)

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KW-8232 free base 相关抗体:
体内研究
(In Vivo)

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male Sprague-Dawley rats (5-week-old)[1].
Dosage: 1, 3, 10, and 30 mg/kg.
Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
分子量

609.16

Formula

C36H37ClN4O3
CAS 号
性状

固体

颜色

Off-white to pink

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (276 KB)

产品使用指南 (1538 KB)
参考文献

KW-8232 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KW-8232170365-25-0KW8232KW 8232Prostaglandin ReceptorSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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目录号：
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