2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Leucylarginylproline

Leucylarginylproline是血管紧张素转换酶 (ACE) 抑制剂，IC50值为0.27μM。

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Leucylarginylproline Chemical Structure

Leucylarginylproline Chemical Structure

CAS No. : 133943-59-6

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规格 价格 是否有货 数量
1 mg ￥1494
1 - 2 周
5 mg   询价  
10 mg   询价  

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Leucylarginylproline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

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  • 参考文献

生物活性

Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.

IC50 & Target

IC50: 0.27μM (ACE)[1]
体外研究
(In Vitro)

Intravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection[1]. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leucylarginylproline 相关抗体:
分子量

384.47

Formula

C17H32N6O4
CAS 号
Sequence

Leu-Arg-Pro
Sequence Shortening

LRP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Kinase Assay
[1]

Hip-His-Leu (5mM) and an ACE inhibitor (Leucylarginylproline) are dissolved in a 100 mM sodium borate buffer (pH 8.3) containing 300 mM NaCl, and incubated for 30 min with 8 milliunits of ACE at 37°C. The ACE inhibitor concentration required to inhibit 50% of the ACE activity under the above conditions is defined as IC50[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Rats: Leucylarginylproline is dissolved in 1.0 mM normal saline. After being warmed up, rats are orally administered (0.18 mmol/kg bw) with peptides or normal saline (control). Tail systolic blood pressures are measured at 2-h intervals (0, 2, 4, 6, 8, 10, and 12 h) after the administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Leucylarginylproline 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Leucylarginylproline133943-59-6Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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目录号：
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